RNA degradome--its biogenesis and functions
نویسندگان
چکیده
منابع مشابه
RNA degradome—its biogenesis and functions
RNA degradation is among the most fundamental processes that occur in living cells. The continuous decay of RNA molecules is associated not only with nucleotide turnover, but also with transcript maturation and quality control. The efficiency of RNA decay is ensured by a broad spectrum of both specific and non-specific ribonucleases. Some of these ribonucleases participate mainly in processing ...
متن کاملMicroRNAs: biogenesis and molecular functions.
Small regulatory RNAs are essential and ubiquitous riboregulators that are the key mediators of RNA interference (RNAi). They include microRNAs (miRNAs) and short-interfering RNAs (siRNAs), classes of approximately 22 nucleotide RNAs. miRNAs and siRNAs bind to Argonaute proteins and form effector complexes that regulate gene expression; in animals, this regulation occurs primarily at the post-t...
متن کاملRNA Degradome Studies Give Insights into Ribosome Dynamics.
RNA metabolism is key to a number of crucial processes in the cell including transcription, RNA splicing, translation, and gene regulation. For efficient translation, mature mRNAs must have a 7methylguanosine cap on the 5' end to help recruit the translation machinery, and protect the mRNA from exonucleases. If the cap is removed during RNA degradation, a free 5' monophosphate is revealed. Like...
متن کاملBiogenesis, delivery, and function of extracellular RNA
The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the me...
متن کاملNeurotrophin signaling endosomes: biogenesis, regulation, and functions.
In the nervous system, communication between neurons and their post-synaptic target cells is critical for the formation, refinement and maintenance of functional neuronal connections. Diffusible signals secreted by target tissues, exemplified by the family of neurotrophins, impinge on nerve terminals to influence diverse developmental events including neuronal survival and axonal growth. Key me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2011
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkr450